Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States
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چکیده
• In Figure 2, panel C was incorrect (duplicating panel B). The correct version of Figure 2 now appears in the article and is presented here. • In Figure 5, on page 6, a single point estimate marker was omitted from Figure 5. The correct version of Figure 5 now appears in the article and is presented here. • On page 6, left column, first paragraph, line 7, “(HR 1.22; 95% CI 0.92 to 1.62, P=0.16)” has been corrected to “(HR 1.24; 95% CI 0.92 to 1.66, P=0.16).” • In Figure 6, on page 7, the total number of eGFR≥60 was presented as 17073 and has been corrected to 17037. • In the legends to Figures 5 and 6, on pages 6 and 7, respectively, the following explanatory note has been added: “The prior stent subgroup is limited to those who underwent percutaneous revascularization.”
منابع مشابه
Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States
BACKGROUND Vorapaxar is a protease-activated receptor-1 antagonist approved by the U.S. Food and Drug Administration (FDA) for the reduction of thrombotic cardiovascular (CV) events in patients with a history of myocardial infarction (MI) and peripheral artery disease (PAD), without a previous stroke or transient ischemic attack (TIA). METHODS AND RESULTS We examined the efficacy and safety o...
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This article reviews the pharmacology, clinical efficacy, and safety of vorapaxar in reducing cardiovascular risk. Vorapaxar is a tricyclic himbacine-derived reversible inhibitor of platelet surface protease activator receptor-1, which prevents thrombin from activating platelets. Two Phase III clinical trials and multiple subanalyses from the two trials with vorapaxar have been published. In pa...
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عنوان ژورنال:
دوره 4 شماره
صفحات -
تاریخ انتشار 2015